Health Affairs

Health Affairs, 24, no. 1 (2005): 93-101 doi: 10.1377/hlthaff.24.1.93 © 2005 by Project HOPE	New Online   Getting Health Reform Done   After the State of the Union   Incremental Reform   E-Health in Developing World   Most-Read Articles in 2009

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Evaluating Evidence

When Is Evidence Sufficient?

Karl Claxton, Joshua T. Cohen and Peter J. Neumann

Traditional conceptualizations of evidence-based medicine rely heavily on randomized controlled trials. Although initiatives to broaden definitions of evidence have been advanced, they generally have not tied evidentiary criteria formally and quantitatively to the benefits and costs involved in a decision to adopt or reject an intervention. Decision analysis provides a framework for combining information to inform the adoption decision in this manner. Value-of-information analysis, a related methodology, helps to determine whether it is worthwhile to collect additional information as well as the type of research that would be most helpful.

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