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PROLOGUEGenomics
The mapping of the human genome has created the opportunity for early identification of those at risk for a wide range of common, life-threatening diseases. The pace of discovery in the field of genomic research has been accompanied by expectations that cutting-edge, individualized treatments—so-called personalized medicine—may be just around the corner. A fundamental question for stakeholders—researchers, policymakers, and consumers alike—is whether these genomic discoveries are useful and can be translated into actual health care interventions that can practically and cost-effectively find their way into hospitals and doctors offices.
But how much evidence should be required to show that a discovery
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